The School Sisters of Notre Dame have served throughout the St. Louis area since 1858. The province offices and sisters reside at Sancta Maria in Ripa in St. Louis and work throughout the area. They also live in service, prayer and presence at Mother of Perpetual Help, St. Louis, and The Sarah Community, Bridgeton.

The province office includes archives, associates, communications, finance, information technology, ministry office, resource development, support staff, transportation and wellness.